No, Endless is a Linux-based operating system and does not support Windows apps. However, most of the types of apps you find on a Windows (or Mac) operating system are on Endless and we will continue adding more in the near future.
If you have a favorite app that you can't find on Endless OS, let us know on our community forum. There may be something similar that we can recommend for you, or your suggestion might end up influencing our Product Roadmap.
Note: Starting from version 3.0, you can install Endless OS alongside Windows so that you can use any Windows applications that you can’t find on Endless. Please click here for details.